Departamento de Qumica, ICE, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil.
Chem Biol Drug Des. 2011 Nov;78(5):876-80. doi: 10.1111/j.1747-0285.2011.01231.x. Epub 2011 Sep 21.
Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p-octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).
从醇和醛合成了两个系列的芳族和杂芳族氨基酸醇，并对其抗菌活性进行了评估。所有辛基化化合物在琼脂扩散法评估时对测试的四种细菌均显示出更好的活性，因此被选择用于评估最小抑菌浓度。对表皮葡萄球菌（最小抑菌浓度=32μm）而言，对烷氧基苄基衍生物的效果最佳。
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