Faculty of Veterinary Science, University of Sydney, Camden, NSW, Australia.
Zoonoses Public Health. 2012 May;59(3):184-92. doi: 10.1111/j.1863-2378.2011.01431.x. Epub 2011 Aug 25.
An algorithm was developed as a tool to rapidly assess the potential for a new or emerging disease of livestock to adversely affect humans via consumption or handling of meat product, so that the risks and uncertainties can be understood and appropriate risk management and communication implemented. An algorithm describing the sequence of events from occurrence of the disease in livestock, release of the causative agent from an infected animal, contamination of fresh meat and then possible adverse effects in humans following meat handling and consumption was created. A list of questions complements the algorithm to help the assessors address the issues of concern at each step of the decision pathway. The algorithm was refined and validated through consultation with a panel of experts and a review group of animal health and food safety policy advisors via five case studies of potential emerging diseases of cattle. Tasks for model validation included describing the path taken in the algorithm and stating an outcome. Twenty-nine per cent of the 62 experts commented on the model, and one-third of those responding also completed the tasks required for model validation. The feedback from the panel of experts and the review group was used to further develop the tool and remove redundancies and ambiguities. There was agreement in the pathways and assessments for diseases in which the causative agent was well understood (for example, bovine pneumonia due to Mycoplasma bovis). The stated pathways and assessments of other diseases (for example, bovine Johne's disease) were not as consistent. The framework helps to promote objectivity by requiring questions to be answered sequentially and providing the opportunity to record consensus or differences of opinion. Areas for discussion and future investigation are highlighted by the points of diversion on the pathway taken by different assessors.
开发了一种算法,作为一种工具来快速评估新出现的或正在出现的动物疾病通过食用或处理肉类产品对人类产生不利影响的可能性,以便了解风险和不确定性,并实施适当的风险管理和沟通。该算法描述了疾病在牲畜中发生、感染动物释放病原体、鲜肉污染以及随后在人类处理和食用肉类后可能产生的不良影响的事件序列。该算法附有一系列问题,以帮助评估人员在决策路径的每个步骤中解决关注的问题。该算法通过与专家小组和动物健康与食品安全政策顾问审查小组进行五次潜在新发牛病案例研究进行了改进和验证。模型验证的任务包括描述算法中的路径并陈述结果。62 名专家中的 29%对模型发表了评论,其中三分之一的答复者还完成了模型验证所需的任务。专家小组和审查小组的反馈用于进一步开发该工具,并消除冗余和歧义。对于病原体理解较好的疾病(例如由牛支原体引起的牛肺炎),其路径和评估具有一致性。对于其他疾病(例如牛型约翰氏病),其路径和评估则不一致。该框架通过要求按顺序回答问题并提供记录共识或不同意见的机会,有助于提高客观性。不同评估人员采取的不同路径上的分歧点突出了需要讨论和未来调查的领域。