Parkville Branch, Ludwig Institute for Cancer Research, Melbourne, 3050, Australia.
Exp Cell Res. 2011 Nov 15;317(19):2748-58. doi: 10.1016/j.yexcr.2011.08.010. Epub 2011 Aug 22.
In this brief overview we discuss the association between Wnt signaling and colon cell biology and tumorigenesis. Our current understanding of the role of Apc in the β-catenin destruction complex is compared with potential roles for Apc in cell adhesion and migration. The requirement for phosphorylation in the proteasomal-mediated degradation of β-catenin is contrasted with roles for phospho-β-catenin in the activation of transcription, cell adhesion and migration. The synergy between Myb and β-catenin regulation of transcription in crypt stem cells during Wnt signaling is discussed. Finally, potential effects of growth factor regulatory systems, Apc or truncated-Apc on crypt morphogenesis, stem cell localization and crypt fission are considered.
在这篇简要综述中，我们讨论了 Wnt 信号与结肠细胞生物学和肿瘤发生之间的关联。我们目前对 APC 在β-连环蛋白降解复合物中的作用的理解与 APC 在细胞黏附和迁移中的潜在作用进行了比较。在蛋白酶体介导的β-连环蛋白降解中需要磷酸化，而磷酸化β-连环蛋白在转录激活、细胞黏附和迁移中发挥作用。在 Wnt 信号转导过程中，Myb 和β-连环蛋白对转录的协同调控在隐窝干细胞中进行了讨论。最后，还考虑了生长因子调节系统、APC 或截短 APC 对隐窝形态发生、干细胞定位和隐窝分裂的潜在影响。
