抑制与激活经典Wnt信号传导以促进间充质干细胞的软骨分化。综述
Inhibition versus activation of canonical Wnt-signaling, to promote chondrogenic differentiation of Mesenchymal Stem Cells. A review.
作者信息
Schizas Nikitas P, Zafeiris Christos, Neri Anna-Aikaterini, Anastasopoulos Panagiotis P, Papaioannou Nikolaos A, Dontas Ismene A
机构信息
School of Medicine, National and Kapodistrian University of Athens.
Royal Berkshire Hospital NHS FT.
出版信息
Orthop Rev (Pavia). 2021 Aug 2;13(2):27098. doi: 10.52965/001c.27098. eCollection 2021.
Abstract
Canonical Wnt signaling regulation is essential for controlling stemness and differentiation of mesenchymal stem cells (MSCs). However, the mechanism through which canonical Wnt-dependent MSC lineage commitment leads to chondrogenesis is controversial. Some studies hypothesize that inhibition of canonical Wnt signaling induces MSC chondrogenic differentiation, while others support that the pathway should be activated to achieve MSC chondrogenesis. The purpose of the present review is to analyze data from recent studies to elucidate parameters regarding the role of canonical Wnt signaling in MSC chondrogenic differentiation.
摘要
经典Wnt信号通路调控对于控制间充质干细胞（MSC）的干性和分化至关重要。然而，经典Wnt依赖的MSC谱系定向导致软骨形成的机制仍存在争议。一些研究推测，抑制经典Wnt信号通路可诱导MSC向软骨细胞分化，而另一些研究则支持应激活该信号通路以实现MSC软骨形成。本综述的目的是分析近期研究的数据，以阐明有关经典Wnt信号通路在MSC软骨形成分化中作用的参数。
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