Ouyang Shurui, Zheng Xinbin, Zhou Xin, Chen Zhengquan, Yang Xuefeng, Xie Ming
Gastrointestinal Department, Affiliated Hospital of Zunyi Medical College, Guizhou 563000, China.
Oncotarget. 2017 Oct 6;8(54):92815-92826. doi: 10.18632/oncotarget.21590. eCollection 2017 Nov 3.
BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was identified as an oncogene in breast cancer. In our research, we found that the expression level of BCAR4 was upregulated in colon cancer tissues compared to paired normal tissues. What's more, higher BCAR4 expression was correlated with lower survival rate in patients with colon cancer. Mechanistically, we showed that BCAR4 activated Wnt/β-catenin signaling in colon cancer by protecting β-catenin from degradation. We also showed that BCAR4 overexpression promoted cell proliferation and migration in colon cancer. However, silencing BCAR4 inhibited cell growth and promoted apoptosis. Besides, BCAR4 knockdown decreased tumor growth . These findings indicate that BCAR4 facilitated colon cancer progression by enhancing cell proliferation and inhibiting apoptosis via BCAR4/β-catenin axis. BCAR4 may be a useful new target for treatment of patients with colon cancer.
BCAR4（乳腺癌抗雌激素耐药4）是一种长链非编码RNA，在乳腺癌中被鉴定为一种癌基因。在我们的研究中，我们发现与配对的正常组织相比，BCAR4在结肠癌组织中的表达水平上调。此外，BCAR4高表达与结肠癌患者较低的生存率相关。从机制上讲，我们发现BCAR4通过保护β-连环蛋白不被降解来激活结肠癌中的Wnt/β-连环蛋白信号通路。我们还发现BCAR4过表达促进结肠癌细胞的增殖和迁移。然而，沉默BCAR4可抑制细胞生长并促进细胞凋亡。此外，敲低BCAR4可减少肿瘤生长。这些发现表明，BCAR4通过BCAR4/β-连环蛋白轴增强细胞增殖并抑制细胞凋亡，从而促进结肠癌进展。BCAR4可能是治疗结肠癌患者的一个有用的新靶点。
