Department of Chemistry G. Ciamician, University of Bologna, Bologna, Italy.
J Mater Sci Mater Med. 2012 Jun;23(6):1363-70. doi: 10.1007/s10856-012-4618-2. Epub 2012 Apr 21.
In this study we investigated the influence of electrospun polymer fibers on the properties of a α-tricalcium phosphate/gelatin biomimetic cement. To this aim, we added different amounts of poly(L-lactic acid) and poly(lactide-co-glycolide) fibers to the cement composition. Fibers enrichment provoked a significant reduction of both initial and final setting times. Moreover electrospun polymer fibers slowed down the conversion of α-tricalcium phosphate into calcium deficient hydroxyapatite. As a result, the final cements were more compact than the control cement, because of the smaller crystal dimensions and reduced crystallinity of the apatitic phase. The compressive strength, σ(b), and Young's modulus, E, of the control cement decreased significantly after 40 days soaking in physiological solution, whereas the more compact microstructure enabled fiber reinforced cements to maintain their mechanical properties in the long term.
在这项研究中，我们研究了电纺聚合物纤维对 α-磷酸三钙/明胶仿生水泥性能的影响。为此，我们向水泥组合物中添加了不同量的聚（L-乳酸）和聚（乳酸-共-乙醇酸）纤维。纤维的富集显著降低了初始和最终凝固时间。此外，电纺聚合物纤维减缓了 α-磷酸三钙向钙缺乏羟基磷灰石的转化。结果，最终的水泥比对照水泥更致密，因为磷灰石相的晶体尺寸更小且结晶度降低。在生理溶液中浸泡 40 天后，对照水泥的抗压强度 σ(b)和杨氏模量 E 显著降低，而更致密的微观结构使纤维增强水泥能够在长期内保持其机械性能。
