Department of Pathology, Laboratory of Cellular and Molecular Cardiology, University of São Paulo, Ribeirão Preto, Brazil.
Adv Parasitol. 2011;76:83-99. doi: 10.1016/B978-0-12-385895-5.00004-9.
The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A(2) vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.
Chagas 病的心血管表现众所周知。然而，脉管系统，尤其是微血管的作用却很少受到关注。本章综述了微血管改变，尤其是心脏微血管改变在克山病性心肌病发病机制中的作用的相关证据。这些数据可能对理解微血管在其他心肌病发病机制中的作用也很重要。还讨论了内皮素-1 和血栓烷 A2 血管痉挛和血小板聚集的作用。此外，这些观察结果可能为干预提供靶点。
