Molecular Neurobiology Laboratory, Department of Psychiatry, Program in Neuroscience and Harvard Stem Cell Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.
Cell Stem Cell. 2011 Sep 2;9(3):179-81. doi: 10.1016/j.stem.2011.08.004.
Recent publications in Cell Stem Cell (Son et al., 2011; Ambasudhan et al., 2011), PNAS (Pfisterer et al., 2011), and Nature (Caiazzo et al., 2011; Pang et al., 2011; Yoo et al., 2011) report that functional neurons can be directly generated from human fibroblast cells without going through the pluripotent state.
最近在《细胞干细胞》(Cell Stem Cell)(Son 等人,2011;Ambasudhan 等人,2011)、《美国国家科学院院刊》(PNAS)(Pfisterer 等人,2011)和《自然》(Nature)(Caiazzo 等人,2011;Pang 等人,2011;Yoo 等人,2011)上发表的文章报道称,可以直接从人类成纤维细胞生成功能性神经元,而无需经过多能状态。