Department of Obstetrics and Gynaecology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Breast. 2011 Dec;20(6):579-80. doi: 10.1016/j.breast.2011.08.134. Epub 2011 Aug 31.
Assessment of margins when excising ductal carcinoma in situ (DCIS) of the breast is difficult. Frozen section is unreliable and specimen intraoperative radiography only provides information regarding the extent of the visualized lesion or the microcalcifications. A multi-center, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe) in intraoperative margin assessment during breast conserving surgery (BCS) of DCIS, and the associated reduction of re-excisions. We present results for 22 patients, from those enrolled in our institution. The device was used as an adjunctive tool to current practice. Based on permanent histology reporting, the rate of successful procedures was 86%. The improvement in intraoperative assessment with device use was associated with a reduction in re-excision rates, from 38.8 to 18%.
评估乳腺导管原位癌 (DCIS) 的切除边缘比较困难。冰冻切片不可靠，术中放射摄影仅能提供有关可见病变或微钙化程度的信息。进行了一项多中心、单臂研究，以评估一种新型设备（MarginProbe）在乳腺保留手术 (BCS) 中评估 DCIS 术中切缘的益处，以及减少再次切除的可能性。我们展示了来自本机构的 22 名患者的结果。该设备被用作当前实践的辅助工具。基于永久组织学报告，成功手术的比例为 86%。使用该设备进行术中评估的改善与降低再次切除率相关，从 38.8%降至 18%。
