Dept of Kinesiology, University of Wisconsin, Madison, WI, USA.
J Phys Act Health. 2011 Sep;8(7):994-1003. doi: 10.1123/jpah.8.7.994.
We examined the association between ambulatory activity and biological markers of health in smokers.
Baseline data from 985 subjects enrolled in a pharmacologic smoking cessation trial were examined. Body size, blood pressure, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), total and small LDL particles, LDL size, high density lipoprotein cholesterol, triglycerides (TG), C-reactive protein (CRP), creatinine, fasting glucose, and hemoglobin A1c were assessed in relation to pedometer-assessed ambulatory activity, as was the odds of metabolic syndrome and CRP > 3 mg/L. Effect modification by gender was examined.
Only waist circumference was lower with greater steps/day in the men and women combined (P(trend) < 0.001). No other significant relationships were noted in men, while women with ≥ 7500 steps/day had lower weight, BMI, CRP, TG, total, and small LDL particles compared with those with < 7500 steps/day. These women also had 62% and 43% lower odds of metabolic syndrome and elevated CRP, respectively, compared with the less active women. Adjustment for BMI attenuated all the associations seen in women.
Greater ambulatory activity is associated with lower levels of metabolic and cardiovascular risk factors in female smokers which may, in part, be mediated by a reduction in BMI.
我们研究了吸烟者的日常活动与健康生物标志物之间的关系。
对参加药物戒烟试验的 985 名受试者的基线数据进行了检查。评估了与计步器评估的日常活动相关的身体大小、血压、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL-C)、总和小 LDL 颗粒、LDL 大小、高密度脂蛋白胆固醇、甘油三酯 (TG)、C-反应蛋白 (CRP)、肌酐、空腹血糖和血红蛋白 A1c，还评估了代谢综合征和 CRP > 3mg/L 的可能性与日常活动之间的关系，并检查了性别对其的影响。
仅在男性和女性综合组中，每日步数越多腰围越小（P<0.001）。在男性中未发现其他显著关系，而每日步数≥7500 步的女性体重、BMI、CRP、TG、总 LDL 颗粒和小 LDL 颗粒均低于每日步数<7500 步的女性。与不活跃的女性相比，这些女性患代谢综合征和 CRP 升高的几率分别降低了 62%和 43%。调整 BMI 后，女性的所有关联均减弱。
在女性吸烟者中，日常活动量越大，代谢和心血管风险因素的水平越低，这可能部分是由于 BMI 的降低所致。
