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[从生活质量角度看直肠癌外科治疗的进展]

[Developments in the surgical treatment of rectal cancer in view of the quality of life].

作者信息

Kato T, Hirai T, Yasui K, Nakazato H

机构信息

Dept. of Gastroenterological Surgery, Aichi Cancer Center Hospital.

出版信息

Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 2):741-6.

PMID:2188596
Abstract

The quality of life of patients who had undergone a primary radical resection of the rectum for cancer was restricted by colostomy, urinary incontinence or sexual disturbance. This paper describes the developments and surgical results of sphincter saving operation and nerve preserving operation for rectal cancer. 1) Sphincter saving operation: With the advent of modern sphincter saving techniques such as low anterior resection and stapling technique, abdomino-perineal resection of the rectum are no longer necessary for the treatment of nearly all tumors of rectosigmoid, three of four tumors of the upper rectum and one of five tumors of the lower rectum. At low anterior resection of the rectum, in general principle, the affected parts of the diseased rectum were resected with a macroscopically free margin of at least 3 cm on anal side of the cancer. Recurrence rates of anterior resection were fewer than those of abdomino-perineal resection, and five year survival rates after AR were better than those of after APR. 2) Autonomic nerve preserving operation: As it is impossible to remove the internal iliac lymph-nodes completely without disturbing the underlying pelvic plexus, an autonomic nerve preserving operation was done unless there was microscopic lymphatic gland involvement by frozen section. Urinary bladder function was impaired in 80% of patients after extended lateral dissection without nerve preservation whereas it was unaffected in 14 of 16 patients after nerve preserving operation. Six of seven male patients with nerve preserving operation retained potency, but only one was capable of ejaculation.

摘要

因行结肠造口术、尿失禁或性功能障碍,直肠癌根治性切除术后患者的生活质量受到限制。本文介绍了直肠癌保肛手术及保留神经手术的进展和手术结果。1) 保肛手术:随着低位前切除术和吻合器技术等现代保肛技术的出现,几乎所有直肠乙状结肠肿瘤、四分之三的上段直肠癌和五分之一的下段直肠癌的治疗不再需要行腹会阴联合直肠癌切除术。在直肠癌低位前切除术中,一般原则是在癌肿肛门侧至少切除3cm肉眼可见的切缘。前切除术的复发率低于腹会阴联合切除术,低位前切除术后的5年生存率优于腹会阴联合切除术后。2) 保留自主神经手术:由于不干扰其下方的盆腔神经丛就不可能完全切除髂内淋巴结,所以除非冰冻切片显示有微小淋巴结受累,否则都要进行保留自主神经手术。在未保留神经的扩大侧方淋巴结清扫术后,80%的患者膀胱功能受损,而在保留神经手术的16例患者中有14例膀胱功能未受影响。在7例接受保留神经手术的男性患者中,6例保留了性功能,但只有1例能够射精。

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