Demir Mehmet, Demir Canan
Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.
South Med J. 2011 Aug;104(8):543-6. doi: 10.1097/SMJ.0b013e31822462e2.
Hepatitis secondary to infection with the hepatitis C virus (HCV) is one of the most common causes of viral hepatitis worldwide. Multiple extrahepatic manifestations of HCV infection have been recognized. Dilated and hypertrophic cardiomyopathy associated with HCV infection have been recently described in the literature; however, the effect of HCV infection on the left ventricular systolic and diastolic functions is unknown. Therefore, in this study we aimed to examine left ventricular systolic and diastolic functions in HCV patients.
The study included 50 anti-HCV positive patients and 50 persons for control groups. We performed transthorasic echocardiography and P-wave analysis on all participants. We compared left ventricle diastolic parameters, left ventricle ejection fraction, and P-wave dispersion (Pd) between these two groups. In the group with anti-HCV positivity, the ratio of E/A was found to be lower (1.2 ± 0.7 and 1.37 ± 0.6, P = 0.003); the ratio of E/Em was found to be higher (7.6 ± 1.51 and 6.8 ± 1.72, P = 0.0001). Maximum P-wave duration (Pmax) and Pd were higher in the patient group (99.3 ± 8 and 82.4 ± 7.8, P = 0.004; 44.1 ± 0.9 and 25.3 ± 1.5, P = 0.001). No other statistically significant difference was found between the two groups with regard to the left ventricle systolic and diastolic parameters.
Our findings show that HCV infection may be associated with left ventricular systolic and diastolic dysfunction and cardiac arrhythmias.
丙型肝炎病毒（HCV）感染继发的肝炎是全球病毒性肝炎最常见的病因之一。HCV感染的多种肝外表现已得到认可。近期文献报道了与HCV感染相关的扩张型和肥厚型心肌病；然而，HCV感染对左心室收缩和舒张功能的影响尚不清楚。因此，在本研究中，我们旨在检查HCV患者的左心室收缩和舒张功能。
该研究纳入50例抗HCV阳性患者和50例作为对照组的人员。我们对所有参与者进行了经胸超声心动图检查和P波分析。我们比较了两组之间的左心室舒张参数、左心室射血分数和P波离散度（Pd）。在抗HCV阳性组中，发现E/A比值较低（1.2±0.7和1.37±0.6，P = 0.003）；E/Em比值较高（7.6±1.51和6.8±1.72，P = 0.0001）。患者组的最大P波时限（Pmax）和Pd较高（99.3±8和82.4±7.8，P = 0.004；44.1±0.9和25.3±1.5，P = 0.001）。两组在左心室收缩和舒张参数方面未发现其他统计学上的显著差异。
我们的研究结果表明，HCV感染可能与左心室收缩和舒张功能障碍以及心律失常有关。
