肉毒杆菌毒素A治疗单侧水源性角化病
Unilateral aquagenic keratoderma treated with botulinum toxin A.
作者信息
Houle Marie-Claude, Al Dhaybi Rola, Benohanian Antranik
机构信息
Department of Dermatology, University of Montreal, Montreal, Quebec, Canada.
出版信息
J Dermatol Case Rep. 2010 Apr 11;4(1):1-5. doi: 10.3315/jdcr.2010.1045.
BACKGROUND
Aquagenic keratoderma is a rare transient disease that occurs after water immersion and disappears shortly after drying. Most cases involve the palms and fingers bilaterally but it can also affect the soles. Few cases have been associated with drugs but its pathogenesis remains unclear.
MAIN OBSERVATION
We report a 60-year-old man with a 30-year-history of aquagenic keratoderma of the right palm without associated hyperhidrosis or history of drug intake. After unsuccessful treatment with 15% aluminium chloride hexahydrate gel, botulinum toxin A injections led to significant improvement within 2 weeks.
CONCLUSIONS
To our knowledge, this case is the first report of idiopathic unilateral aquagenic keratoderma in the medical literature. It is the third report of successful treatment with botulinum toxin A which is in favor of a role of sweat glands in the pathogenesis of aquagenic keratoderma.
背景
水源性角化病是一种罕见的短暂性疾病，在水浸泡后出现，干燥后不久消失。大多数病例双侧累及手掌和手指，但也可累及足底。少数病例与药物有关，但其发病机制尚不清楚。
主要观察结果
我们报告一名60岁男性，有30年右手掌水源性角化病病史，无相关多汗症或药物摄入史。在用15%六水合氯化铝凝胶治疗失败后，注射A型肉毒杆菌毒素在2周内导致显著改善。
结论
据我们所知，该病例是医学文献中特发性单侧水源性角化病的首例报告。这是A型肉毒杆菌毒素成功治疗的第三例报告，支持汗腺在水源性角化病发病机制中的作用。
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