Tomov S V, Flume P A, Stenbit A E, Ullian M E
Department of Medicine, Divisions of Nephrology, Medical University of South Carolina, South Carolina, USA.
Indian J Nephrol. 2011 Jul;21(3):194-7. doi: 10.4103/0971-4065.82637.
We present the case of a 58-year-old male with chronic kidney disease who was admitted to the hospital multiple times with extracellular fluid volume depletion and prerenal azotemia. Some episodes were associated with gastrointestinal fluid losses and others with profuse diaphoresis in the absence of gastrointestinal fluid losses. At the age of 57 years, a common cystic fibrosis transmembrane conductance regulator protein mutation and a family history of cystic fibrosis were documented. We hypothesize that the abnormal cystic fibrosis transmembrane conductance regulator resulted in repeated bouts of excessive sweating, extracellular fluid volume depletion, and acute renal failure. This case is unique because of the prolonged period of time over which multiple documented episodes of prerenal acute renal failure occurred and because of the onset of the episodes in adulthood.
我们报告了一例58岁的慢性肾脏病男性患者，该患者因细胞外液容量减少和肾前性氮质血症多次入院。有些发作与胃肠道液体丢失有关，另一些则与大量出汗有关，且无胃肠道液体丢失。57岁时，记录到常见的囊性纤维化跨膜传导调节蛋白突变及囊性纤维化家族史。我们推测，异常的囊性纤维化跨膜传导调节蛋白导致反复出现多汗、细胞外液容量减少及急性肾衰竭。该病例独特之处在于，有多次记录在案的肾前性急性肾衰竭发作，且发作持续时间较长，并且发作始于成年期。
