Gharaibeh Almutez, Khassawneh Mohammed, Khriesat Wadah, Alkhatib Shadi, Migdadi Yazan
Department of Special Surgery-Division of Ophthalmology, The University of Jordan, Amman, Jordan.
Middle East Afr J Ophthalmol. 2011 Jul;18(3):209-13. doi: 10.4103/0974-9233.84047.
To describe retinopathy of prematurity (ROP) among Jordanian preterm infants and evaluate the efficacy of applying current Western screening guidelines for Jordanian preterms.
In this retrospective, descriptive hospital-based study, we collected data on preterm infants who were referred by their neonatologist for ROP screening at King Abdullah University Hospital between July 2006 and June 2007. Guidelines suggested by the American Academy of Pediatrics were followed. Additionally, older preterms considered at risk for ROP by the neonatal intensive care unit were screened. Any neonate with stage 1 ROP or higher in either eye was considered a positive case of ROP.
Ninety-one preterms were included in the study. The median birth weight was 1390 gm (range,730-1980 gms) and the gestational age ranged from 26 to 35 weeks with 64.8% of preterms ≤ 32 weeks. ROP occurred in 28.6% of all patients, in 20% of infants with birth weight greater than 1500 gms and in 9.4% of preterms with gestational age ≥ 32 weeks. Six patients (6.6%) required laser treatment, two with low birth weight greater than 1250 gm and one was 33 weeks of age. Consanguinity was identified in 19.2% of infants with ROP while consanguinity in infants who did not develop ROP was 1.9%. This difference was statistically significant (P<0.05).
ROP occurs in premature infants in Jordan with gestational age above 32 weeks and birth weight above 1250 gm. Future guidelines for screening should incorporate the current study outcomes. A prospective, population-based is required to set national guidelines for ROP screening in the Jordanian population and similarly for different populations worldwide. Consanguinity may play a role in ROP development and further genetic studies may aid in elucidating the pathogenesis of ROP.
描述约旦早产儿中的早产儿视网膜病变（ROP），并评估将当前西方筛查指南应用于约旦早产儿的有效性。
在这项基于医院的回顾性描述性研究中，我们收集了2006年7月至2007年6月期间在阿卜杜拉国王大学医院由新生儿科医生转诊进行ROP筛查的早产儿的数据。遵循美国儿科学会建议的指南。此外，新生儿重症监护病房认为有ROP风险的较大早产儿也接受了筛查。任何一只眼睛患有1期或更高期ROP的新生儿被视为ROP阳性病例。
91名早产儿纳入研究。中位出生体重为1390克（范围730 - 1980克），胎龄为26至35周，64.8%的早产儿≤32周。所有患者中28.6%发生ROP，出生体重超过1500克的婴儿中20%发生ROP，胎龄≥32周的早产儿中9.4%发生ROP。6名患者（6.6%）需要激光治疗，其中2名出生体重超过1250克且体重低，1名年龄为33周。在发生ROP的婴儿中，19.2%存在近亲结婚，而未发生ROP的婴儿中近亲结婚率为1.9%。这种差异具有统计学意义（P<0.05）。
约旦胎龄超过32周且出生体重超过1250克的早产儿会发生ROP。未来的筛查指南应纳入当前研究结果。需要进行一项基于人群的前瞻性研究，以制定约旦人群以及全球不同人群ROP筛查的国家指南。近亲结婚可能在ROP发展中起作用，进一步的基因研究可能有助于阐明ROP的发病机制。
