Akiyama K, Inoue K, Senshu T
Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, Japan.
Cell Biol Int Rep. 1990 Mar;14(3):267-73. doi: 10.1016/s0309-1651(05)80009-8.
We have performed an immunocytochemical study of peptidylarginine deiminase (EC 3.5.3.15) in various rat tissues using an antiserum to the enzyme purified from rat skeletal muscle. Staining was observed in skeletal muscle fibers, glia cells of the central nervous system, serous cells of submandibular gland, demilunar cells (serous cells) of sublingual gland, uterine endometrium and myometrium, and certain cells in the lamina propria of intestinal villi. Possible involvement of the enzyme in multiple cellular processes were discussed.
我们使用从大鼠骨骼肌中纯化的该酶的抗血清，对各种大鼠组织中的肽基精氨酸脱亚氨酶（EC 3.5.3.15）进行了免疫细胞化学研究。在骨骼肌纤维、中枢神经系统的神经胶质细胞、下颌下腺的浆液细胞、舌下腺的半月细胞（浆液细胞）、子宫内膜和子宫肌层以及肠绒毛固有层中的某些细胞中观察到染色。讨论了该酶可能参与多种细胞过程。
