The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark.
J Nephrol. 2011 Sep-Oct;24(5):537-40. doi: 10.5301/jn.5000009.
Glomerular hyperfiltration (>140 ml/min per 1.73 m2 body surface area) is found in early diabetes and is associated with a poor prognosis with respect to the development of diabetic kidney disease. This review addresses recent investigations and discussions of the following hypotheses behind diabetic hyperfiltration: Increased proximal tubular volume reabsorption results in a pressure drop in Bowman's capsule which increases glomerular filtration rate (GFR). Proximal tubular hyperreabsorption induces an increase in GFR mediated by tubuloglomerular feedback. Dietary NaCl restriction results in a paradoxically increased GFR and increased urine volume in diabetic animals.
肾小球高滤过（>140ml/min/1.73m2 体表面积）见于糖尿病早期，与糖尿病肾病的发展预后不良有关。这篇综述讨论了以下关于糖尿病高滤过背后假说的最新研究：增加近端肾小管的重吸收量会导致在肾小球囊内产生压力下降，从而增加肾小球滤过率（GFR）。近端肾小管的过度重吸收通过管球反馈引起 GFR 的增加。饮食中 NaCl 限制导致糖尿病动物的 GFR 异常增加和尿量增加。
