Lopes da Rosa Jessica, Kaufman Paul D
Biochim Biophys Acta. 2012 Mar;1819(3-4):349-55. doi: 10.1016/j.bbagrm.2011.08.007. Epub 2011 Aug 24.
Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
白色念珠菌是最常见的人类真菌病原体。为了成功传播感染，这种生物体依赖于改变形态、表达与毒力相关的基因以及抵抗宿主免疫系统造成的DNA损伤的能力。其中许多事件涉及对毒力至关重要的染色质改变。本综述将聚焦于已开展的关于染色质功能如何影响白色念珠菌及其他真菌致病性的研究。本文是名为“组蛋白伴侣与染色质组装”的特刊的一部分。
