Department of Surgery, Wright State University Boonshoft School of Medicine, Miami Valley Hospital, One Wyoming Street, WCHE 7000, Dayton, OH 45409, USA.
Surg Clin North Am. 2011 Oct;91(5):1079-87. doi: 10.1016/j.suc.2011.06.007.
Gastrointestinal stromal tumors (GIST) are a unique class of mesenchymal tumors identified within the past decade. Intense molecular and genetic study has been used to characterize these tumors and develop treatment strategies. Although the mainstay of treatment remains surgical resection, therapy targeted at inhibiting tyrosine kinases has had dramatic results. Because of the rapid accumulation of information about the diagnosis and treatment of these tumors, the National Comprehensive Cancer Network convened a GIST task force to provide updated recommendations in 2010. As understanding of these tumors advances, rapid changes in recommendations will continue and should warrant regular updates in tumor management.
胃肠道间质瘤（GIST）是过去十年中发现的一种独特的间叶性肿瘤。通过深入的分子和遗传学研究，对这些肿瘤进行了特征描述并制定了治疗策略。尽管手术切除仍然是主要的治疗方法，但针对抑制酪氨酸激酶的治疗方法已经取得了显著的效果。由于关于这些肿瘤的诊断和治疗的信息迅速积累，美国国家综合癌症网络（National Comprehensive Cancer Network）召集了一个 GIST 工作组，以便在 2010 年提供最新的建议。随着对这些肿瘤的认识不断提高，建议的快速变化将继续，肿瘤管理也应该定期更新。
