Feng Fan, Tian Yangzi, Liu Zhen, Xu Guanghui, Liu Shushang, Guo Man, Lian Xiao, Fan Daiming, Zhang Hongwei
Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Oncotarget. 2016 Jun 28;7(26):40735-40745. doi: 10.18632/oncotarget.9196.
Due to the extremely rare incidence, data about colonic GISTs are limited. Therefore, aim of the present study was to explore clinicopathological characteristics and prognosis of colonic GISTs.
Colonic GISTs cases were obtained from our center and from case report and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed.
There were 79 colonic GISTs patients with a female predominance. The median age was 66 years (range 0.17-84). The median tumor size was 5.8 cm (range 0.5-29). The most common location was sigmoid colon (45.8%), followed by transverse colon (19.5%). The majority of colonic GISTs were high risk (70.8%). Mitotic index was correlated with gender (P = 0.002) and tumor size (P = 0.005), and tumor location was correlated with age (P = 0.017). The five year DFS and DSS were 57.4% and 61.6%, respectively. Mitotic index and NIH risk classification were associated with prognosis of colonic GISTs. However, mitotic index was the only independent risk factor. The distribution of tumor size and NIH risk classification were significantly different between colonic and gastric GISTs (both P = 0.000). The DFS and DSS of colonic GISTs were significantly lower than that of gastric GISTs (P = 0.012 and P = 0.002, respectively).
The most common location for colonic GISTs was sigmoid colon. Most tumors were high risk. Mitotic index was the only independent risk factor for prognosis of colonic GISTs. Colonic GISTs differ significantly from gastric GISTs in respect to clinicopathological features. The prognosis of colonic GISTs was worse than that of gastric GISTs.
由于结肠胃肠道间质瘤（GIST）的发病率极低，相关数据有限。因此，本研究旨在探讨结肠GIST的临床病理特征及预后情况。
收集来自本中心以及从MEDLINE中提取的病例报告和临床研究中的结肠GIST病例。分析其临床病理特征及生存情况。
79例结肠GIST患者中女性居多。中位年龄为66岁（范围0.17 - 84岁）。中位肿瘤大小为5.8 cm（范围0.5 - 29 cm）。最常见的部位是乙状结肠（45.8%），其次是横结肠（19.5%）。大多数结肠GIST为高危（70.8%）。有丝分裂指数与性别（P = 0.002）和肿瘤大小（P = 0.005）相关，肿瘤部位与年龄（P = 0.017）相关。五年无病生存率（DFS）和总生存率（DSS）分别为57.4%和61.6%。有丝分裂指数和美国国立卫生研究院（NIH）风险分级与结肠GIST的预后相关。然而，有丝分裂指数是唯一的独立危险因素。结肠和胃GIST在肿瘤大小分布和NIH风险分级方面存在显著差异（P均 = 0.000）。结肠GIST的DFS和DSS显著低于胃GIST（分别为P = 0.012和P = 0.002）。
结肠GIST最常见的部位是乙状结肠。大多数肿瘤为高危。有丝分裂指数是结肠GIST预后的唯一独立危险因素。结肠GIST在临床病理特征方面与胃GIST有显著差异。结肠GIST的预后比胃GIST差。
