Rath R N, Patel D K, Das P K, Das B K, Mishra A C, Sahu R N, Mohanty G
Department of Medicine, SCB Medical College, Cuttack.
Indian J Med Res. 1990 Mar;91:129-32.
Fifteen (34.8%) of 43 patients of falciparum malaria screened for urinary abnormalities showed significant proteinuria (greater than 150 mg/24 h), haematuria (greater than 1/HPF) and casts, with or without azotaemia. Light microscopic examination of renal biopsy tissue from 12 patients revealed mesangial and endothelial proliferative change in 8, and acute tubular necrosis in one patient. Immunofluorescence showed IgM alone, or IgG and IgM along with C3, in 7 patients within the mesangium or along the capillary walls. Repeat kidney biopsy after 6 wk in 5 patients revealed no residual pathology indicating the reversible nature of the lesions.
在43例接受尿异常筛查的恶性疟患者中，15例（34.8%）出现显著蛋白尿（大于150mg/24小时）、血尿（大于1/HPF）和管型，伴或不伴有氮质血症。对12例患者的肾活检组织进行光镜检查发现，8例有系膜和内皮细胞增生性改变，1例有急性肾小管坏死。免疫荧光显示，7例患者在系膜内或毛细血管壁有单独的IgM，或伴有C3的IgG和IgM。5例患者在6周后重复肾活检，未发现残留病变，表明病变具有可逆性。
