Durga R, Sridhar P, Polasa H
Department of Microbiology, Osmania University, Hyderabad.
Indian J Med Res. 1990 Jan;91:18-20.
Plumbagin, a compound derived from the roots of Plumbago zeylanica (Chitramool) was studied for its effect on the development of antibiotic resistance using antibiotic sensitive strains of Escherichia coli and Staphylococcus aureus. A delayed growth was seen when these organisms were inoculated into the antibiotic (streptomycin/rifampicin) medium, due to development of resistance in some of the cells. However, the growth was completely prevented when the bacteria were grown in the medium containing antibiotic and plumbagin together, and this was attributed to prevention of development of antibiotic resistant cells.
使用大肠杆菌和金黄色葡萄球菌的抗生素敏感菌株，研究了从白花丹（Chitramool）根中提取的化合物白花丹素对抗生素耐药性发展的影响。当将这些微生物接种到抗生素（链霉素/利福平）培养基中时，由于一些细胞产生了耐药性，观察到生长延迟。然而，当细菌在含有抗生素和白花丹素的培养基中一起培养时，生长被完全抑制，这归因于防止了抗生素耐药细胞的产生。
