Büchner S A, Rufli T
Dermatologische Universitätsklinik Basel.
Hautarzt. 1990 Mar;41(3):155-7.
A 47-year-old woman with a solitary morphoea profunda on the flexor aspect of the left thigh is described. Clinically the lesion is characterized by a circumscribed, deeply indurated sclerotic plaque. The main histopathological features were sclerotic collagen changes and a striking accumulation of inflammatory cells in the deep dermis as well as in the subcutaneous tissue. Plasma cells and T- and B-lymphocytes were the predominant cellular components of the infiltrate. The patient had an elevated serum titre of antibodies to Borrelia burgdorferi. The patient was treated with penicillin, which brought about a remarkable improvement. These findings provide further support for the concept that in some cases morphoea profunda may be a manifestation of Borrelia infection.
本文描述了一名47岁女性，其左大腿屈侧出现单发的深部硬斑病。临床上，该病变的特征为边界清楚、深部硬结的硬化斑块。主要组织病理学特征为硬化性胶原改变，以及真皮深层和皮下组织中炎性细胞的显著聚集。浆细胞以及T淋巴细胞和B淋巴细胞是浸润的主要细胞成分。该患者抗伯氏疏螺旋体抗体的血清滴度升高。患者接受青霉素治疗后病情显著改善。这些发现进一步支持了深部硬斑病在某些情况下可能是伯氏疏螺旋体感染表现的观点。
