Weidenthaler B, Roux M, Moter S E, Schulze H J, Kramer M D
Institut für Immunologie und Serologie, Universität Heidelberg.
Hautarzt. 1994 Mar;45(3):171-5. doi: 10.1007/s001050050058.
We report on a 61-year-old patient with sclerodermiform skin lesions of the extremities and polyneuropathy. Borrelia (B.) burgdorferi DNA was detected in lesional skin by the polymerase chain reaction. Serological testing revealed IgG antibodies to B. burgdorferi. Histology revealed an inflammatory stage of a sclerotic reaction in the lesional skin. The admixture of plasma cells and the perineural distribution of the cellular infiltrate was suggestive for a borrelia infection. Immunohistochemical staining for the B. burgdorferi flagellin (41 kDa) revealed a positive staining reaction in the epidermis of lesional skin. The improvement of both the dermatological and the neurological symptoms upon antibiotic treatment with ceftriaxone was taken as further support for the diagnosis of a. B. burgdorferi infection.
我们报告了一名61岁患有四肢硬皮病样皮肤病变和多发性神经病的患者。通过聚合酶链反应在病变皮肤中检测到伯氏疏螺旋体（Borrelia burgdorferi）DNA。血清学检测显示针对伯氏疏螺旋体的IgG抗体。组织学显示病变皮肤中硬化反应的炎症阶段。浆细胞的混合以及细胞浸润的神经周围分布提示伯氏疏螺旋体感染。针对伯氏疏螺旋体鞭毛蛋白（41 kDa）的免疫组织化学染色显示病变皮肤表皮中有阳性染色反应。用头孢曲松进行抗生素治疗后皮肤病学和神经学症状的改善被视为对伯氏疏螺旋体感染诊断的进一步支持。
