Dermatology Department, Sagrado Corazón Hospital, Barcelona, Spain.
Vaccine. 2011 Oct 13;29(44):7602-5. doi: 10.1016/j.vaccine.2011.08.023. Epub 2011 Sep 1.
We carried out a matched case-control study to analyze the possible association between exposure to the children and the risk of suffering herpes-zoster in adulthood. Cases of herpes zoster in immunocompetent healthy patients aged ≥ 25 years seen in the dermatology department of the Sagrado Corazón Hospital in 2007-2008 were matched with four controls. Data were analyzed using conditional logistic regression. 153 cases and 604 matched controls were included. Contacts with children were significantly associated with a reduction in the risk of suffering herpes zoster in adulthood (adjusted OR 0.56 [0.37-0.85]). Herpes-zoster vaccination in immunocompetent people aged ≥ 50 years could counteract the possible negative effects of mass varicella vaccination in childhood on the epidemiology of herpes zoster in adults.
我们进行了一项病例对照研究，以分析儿童暴露与成年人患带状疱疹风险之间的可能关联。在 2007 年至 2008 年期间，在萨格拉多科拉松医院皮肤科就诊的免疫功能正常的健康患者中，年龄≥25 岁的带状疱疹病例与 4 名对照相匹配。使用条件逻辑回归分析数据。共纳入 153 例病例和 604 名匹配对照。与儿童接触与成年后患带状疱疹的风险降低显著相关（调整后的 OR 0.56 [0.37-0.85]）。对年龄≥50 岁的免疫功能正常人群进行带状疱疹疫苗接种，可以抵消儿童大规模水痘疫苗接种对成年人带状疱疹流行病学的可能负面影响。
