肥胖与乳腺癌之间关系的激素机制。
Hormonal mechanisms underlying the relationship between obesity and breast cancer.
机构信息
School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK.
出版信息
Endocrinol Metab Clin North Am. 2011 Sep;40(3):485-507, vii. doi: 10.1016/j.ecl.2011.05.010. Epub 2011 Jul 8.
Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
鉴于全球肥胖症的流行，患有乳腺癌的女性不可避免地会越来越多地出现这种共病；因此，了解其对这种疾病的影响至关重要。这篇综述重点关注肥胖对乳腺癌发展和进展的影响，并描述了可能导致这些观察结果的激素因素，特别强调了雌激素、胰岛素/胰岛素样生长因子轴和脂肪因子的作用。
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