Lorincz A M, Sukumar S
Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 410 CRB, Baltimore, MD 21231-1000, USA.
Endocr Relat Cancer. 2006 Jun;13(2):279-92. doi: 10.1677/erc.1.00729.
Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.
乳腺癌在美国和全球范围内仍是女性面临的一个主要健康问题。有必要识别并采取措施改变可改变的乳腺癌风险因素。肥胖和超重状况已成为达到流行程度的风险因素。本文综述了文献中的证据，这些证据检验了基于机制的假说，这些假说试图为肥胖与乳腺癌风险之间的因果联系提供分子基础，特别是代谢综合征和胰岛素抵抗的影响、脂肪组织中的外周雌激素芳香化以及脂肪因子的直接作用。还讨论了未来的研究领域及对治疗的启示。
