Brain and Spinal Injury Center, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA.
Rev Neurol (Paris). 2011 Oct;167(10):746-50. doi: 10.1016/j.neurol.2011.07.005. Epub 2011 Sep 1.
Ionizing irradiation for the treatment of malignant brain tumors has associated with it a risk of inducing serious morphologic and functional deficits. While obvious tissue damage generally occurs after relatively high radiation doses, cognitive impairment can be seen after lower exposures. The mechanisms responsible for cognitive injury are not well understood, but may involve neurogenesis, a process that is affected by microenvironmental factors including oxidative stress and inflammation. In addition, damage to neurons, either directly or through environmental influences may have a profound impact on cognition. The relationships between cellular response, environmental factors and behavior are complex and difficult to study. However, understanding such issues should provide critical information relevant to the development of strategies and approaches to ameliorate or treat radiation-induced injuries that are associated with behavioral performance.
电离辐射治疗恶性脑肿瘤伴随着诱导严重形态和功能缺陷的风险。虽然在接受相对高剂量的辐射后通常会发生明显的组织损伤，但在低暴露后也可能会出现认知障碍。导致认知损伤的机制尚不清楚，但可能涉及神经发生，这一过程受到包括氧化应激和炎症在内的微环境因素的影响。此外，神经元的损伤，无论是直接的还是通过环境影响，都可能对认知产生深远影响。细胞反应、环境因素和行为之间的关系是复杂的，难以研究。然而，了解这些问题应该为制定改善或治疗与行为表现相关的放射性损伤的策略和方法提供重要信息。
