Center for Mind and Brain, University of California, Davis, Davis California, USA.
Neuroimage. 2012 Jan 16;59(2):1534-9. doi: 10.1016/j.neuroimage.2011.08.034. Epub 2011 Aug 27.
In his novel Ulysses, James Joyce wrote that mistakes are the "…portals of discovery". The present study investigated the pre-stimulus oscillatory EEG signatures of selective attention and motor preparation that predicted failures of overt response inhibition. We employed a trial-by-trial spatial cueing task using a go/no-go response paradigm with bilateral target stimuli. Subjects were required to covertly attend to the spatial location cued on each trial and respond to most of the number targets (go trials) at that location while withholding responses for one designated number (no-go trials). We analyzed the post-cue/pre-target spectral patterns comparing no-go trials in which a response occurred in error (False Alarms, FA) with trials in which participants correctly withheld a response (Correct Rejections, CR). We found that cue-induced occipital alpha (8-12 Hz) lateralization and inter-frequency anti-correlations between the motor beta (18-24 Hz) and pre-frontal theta (3-5 Hz) bands each independently predicted subsequent failures of response inhibition. Based on these findings, we infer that independent perceptual and motor mechanisms operate in parallel to contribute to failures of response inhibition.
在他的小说《尤利西斯》中，詹姆斯·乔伊斯写道，错误是“发现的门户”。本研究调查了选择性注意和运动准备的预刺激脑电振荡特征，这些特征预测了显性反应抑制的失败。我们使用双侧目标刺激的 Go/No-Go 反应范式进行了逐试空间提示任务。要求受试者在每次试验中隐蔽地关注空间位置，并对该位置上的大多数数字目标（Go 试验）做出反应，同时对指定的一个数字（No-Go 试验）保持抑制反应。我们分析了预提示/目标后频谱模式，将出现错误反应（False Alarms，FA）的 No-Go 试验与参与者正确抑制反应的试验（Correct Rejections，CR）进行了比较。我们发现，提示引起的枕部α（8-12 Hz）侧化和运动β（18-24 Hz）和前额叶θ（3-5 Hz）带之间的频间反相关，各自独立预测了随后反应抑制的失败。基于这些发现，我们推断独立的感知和运动机制平行运作，导致反应抑制失败。
