Department of Periodontology, Dental Research Division, Guarulhos University, São Paulo, Brazil.
Arch Oral Biol. 2012 Mar;57(3):293-9. doi: 10.1016/j.archoralbio.2011.08.003. Epub 2011 Sep 3.
The aim of the present study was to evaluate the relationship between glycemic subsets and clinical periodontal conditions in type 2 diabetic Brazilians with generalized chronic periodontitis.
Ninety-one Brazilians with type 2 DM and generalized chronic periodontitis were involved in this study. The clinical examination included full-mouth assessment of plaque index (PI), bleeding on probing (BoP), probing depth (PD), suppuration (SUP), clinical attachment level (CAL) and number of remaining teeth. Blood analyses were carried out for glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG). The relationship between the extent of periodontitis, defined as the percentage of sites with PD and CAL≥5 mm, and glycemic parameters were also analysed. In addition, clinical parameters were compared amongst four (HbA1c levels ≤7.5%, 7.6-9%, 9.1-11% and >11%) and two (<9% and ≥9%) glycemic subsets.
The frequency of uncontrolled diabetic subjects (HbA1c>7.5%) was higher than well-controlled subjects (HbA1c≤7.5%). Amongst the clinical parameters evaluated, only PI was positively correlated with the levels of HbA1c and FPG (p<0.05). The number of remaining teeth was negatively associated with the levels of HbA1c (p<0.05). In addition, PI was significantly higher in subjects presenting HbA1c levels >11% and ≥9% than those with HbA1c levels ≤7.5% and <9%, respectively (p<0.05).
Although an increased frequency of the subjects with generalized chronic periodontitis included presented type 2 uncontrolled DM, a dose-response relationship between the severity and extension of periodontitis and the glycemic control was not established in these subjects.
本研究旨在评估 2 型糖尿病伴广泛慢性牙周炎的巴西患者血糖亚组与临床牙周状况之间的关系。
本研究纳入 91 名患有 2 型糖尿病和广泛慢性牙周炎的巴西人。临床检查包括全口菌斑指数（PI）、探诊出血（BoP）、探诊深度（PD）、溢脓（SUP）、临床附着水平（CAL）和剩余牙齿数量的评估。血液分析包括糖化血红蛋白（HbA1c）和空腹血糖（FPG）。还分析了牙周炎程度（定义为 PD 和 CAL≥5mm 的位点百分比）与血糖参数之间的关系。此外，还比较了四个（HbA1c 水平≤7.5%、7.6-9%、9.1-11%和>11%）和两个（<9%和≥9%）血糖亚组之间的临床参数。
未控制的糖尿病患者（HbA1c>7.5%）的频率高于控制良好的患者（HbA1c≤7.5%）。在所评估的临床参数中，只有 PI 与 HbA1c 和 FPG 水平呈正相关（p<0.05）。剩余牙齿数量与 HbA1c 水平呈负相关（p<0.05）。此外，HbA1c 水平>11%和≥9%的患者的 PI 明显高于 HbA1c 水平≤7.5%和<9%的患者（p<0.05）。
尽管患有广泛慢性牙周炎的患者中未控制的 2 型糖尿病的频率增加，但在这些患者中，牙周炎的严重程度和程度与血糖控制之间没有建立剂量反应关系。
