Stoicescu Manuela, Calniceanu Horea, Țig Ioan, Nemeth Sebastian, Tent Adriana, Popa Adelina, Brisc Ciprian, Ignat-Romanul Ioana
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Department of Periodontology, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.
Exp Ther Med. 2021 Jul;22(1):671. doi: 10.3892/etm.2021.10103. Epub 2021 Apr 23.
The purpose of this research was to assess the correlation between glycemic control and clinical periodontal characteristics in type 2 diabetics with generalized chronic periodontitis. A total of 182 patients with type 2 diabetes mellitus and generalized chronic periodontitis were included in our study. The clinical examination included full-mouth plaque accumulation, bleeding on probing (BoP), probing depth (PD), presence of suppuration (SUP), clinical attachment level (CAL) and number of remaining teeth. Blood analyses were conducted for glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG). The correlation between the extent of periodontitis, defined as the percentage of PD and CAL sites ≥5 mm, and glycemic control was also analyzed. In addition, clinical parameters were compared between two (<7 and ≥7%) glycemic subsets. The frequency of uncontrolled diabetic subjects (HbA1c ≥7%) was higher than that of the well-controlled subjects (HbA1c <7%), 57.15 vs. 42.85%. Among the clinical parameters evaluated, mean full-mouth plaque accumulation was significantly higher among patients without glucose control (74.2±25.2 vs. 62.5±28.7%, P<0.01), as well as mean PD (3.78±0.9 vs. 3.42±0.8 mm, P<0.01) and mean CAL (4.5±1.2 vs. 4.1±1.2 mm, P=0.02). The sites with PD ≥5 mm were statistically more prevalent among patients with HbA1c ≥7% compared with patients with HbA1c <7% (27.8±6.2 vs. 23.4±5.8%, P<0.01). The mean number of remaining teeth was statistically significantly lower in patients with HbA1c ≥7% compared with patients with HbA1c <7% (18.5±3.2 vs. 20.4±4.1, P<0.01). In conclusion, the severity and extension of generalized chronic periodontitis was higher in type 2 diabetes mellitus patients with poor glucose control compared with those with good glucose control.
本研究的目的是评估2型糖尿病合并广泛性慢性牙周炎患者的血糖控制与临床牙周特征之间的相关性。共有182例2型糖尿病合并广泛性慢性牙周炎患者纳入我们的研究。临床检查包括全口菌斑堆积、探诊出血（BoP）、探诊深度（PD）、有无化脓（SUP）、临床附着水平（CAL）和余留牙数量。进行糖化血红蛋白（HbA1c）和空腹血糖（FPG）的血液分析。还分析了牙周炎程度（定义为PD和CAL位点≥5 mm的百分比）与血糖控制之间的相关性。此外，比较了两个血糖亚组（<7%和≥7%）之间的临床参数。血糖控制不佳的糖尿病患者（HbA1c≥7%）的频率高于血糖控制良好的患者（HbA1c<7%），分别为57.15%和42.85%。在评估的临床参数中，未进行血糖控制的患者平均全口菌斑堆积显著更高（74.2±25.2 vs. 62.5±28.7%，P<0.01），平均PD（3.78±0.9 vs. 3.42±0.8 mm，P<0.01）和平均CAL（4.5±1.2 vs. 4.1±1.2 mm，P=0.02）。与HbA（1c）<7%的患者相比，HbA1c≥7%的患者中PD≥5 mm的位点在统计学上更为普遍（27.8±6.2 vs. 23.4±5.8%，P<0.01）。与HbA1c<7%的患者相比，HbA1c≥7%的患者平均余留牙数量在统计学上显著更低（18.5±3.2 vs. 20.4±4.1，P<0.01）。总之，与血糖控制良好的2型糖尿病患者相比，血糖控制不佳的患者广泛性慢性牙周炎的严重程度和范围更高。
