Doebbeling B N, Feilmeier M L, Herwaldt L A
Department of Medicine, University of Iowa, Iowa City 52242.
J Infect Dis. 1990 Jun;161(6):1296-8. doi: 10.1093/infdis/161.6.1296.
A 25-year-old man infected with the human immunodeficiency virus (HIV) presented with paroxysmal cough and dyspnea of 4-months duration. An extensive evaluation including bronchoscopy was negative. A nasopharyngeal swab was positive by direct fluorescent antigen detection and culture for Bordetella pertussis. Respiratory isolation, treatment with erythromycin, and prophylaxis of household contacts was used to eradicate the organism and prevent transmission. Pertussis should be considered as a cause of prolonged cough and dyspnea in patients with HIV infection. The course of this patient was consistent with the concept that cell-mediated immunity is necessary for elimination of B. pertussis.
一名25岁感染人类免疫缺陷病毒（HIV）的男性出现了持续4个月的阵发性咳嗽和呼吸困难。包括支气管镜检查在内的全面评估结果均为阴性。鼻咽拭子通过直接荧光抗原检测和百日咳博德特氏菌培养呈阳性。采用呼吸道隔离、红霉素治疗以及对家庭接触者进行预防，以根除该病原体并防止传播。在HIV感染患者中，应将百日咳视为导致长期咳嗽和呼吸困难的一个原因。该患者的病程与细胞介导免疫对于清除百日咳博德特氏菌是必要的这一概念相符。
