慢性暴露于白细胞介素 6 引起的小脑神经元的神经适应变化。
Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6.
机构信息
Molecular and Integrative Neuroscience Department, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
J Neuroimmunol. 2011 Oct 28;239(1-2):28-36. doi: 10.1016/j.jneuroim.2011.08.009. Epub 2011 Sep 3.
Abstract
IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively little is known about how the elevated levels of IL-6 affect neurons. In the current study we show that under conditions of chronic exposure, IL-6 induces alterations in the level of protein expression in developing CNS cells. Such changes may play a role in the altered CNS function observed in CNS conditions associated with elevated levels of IL-6 in the CNS.
摘要
白细胞介素-6（IL-6）是中枢神经系统（CNS）中的一种重要信号分子。CNS 神经元表达 IL-6 受体及其信号转导分子，这表明 IL-6 在神经元生理学中发挥作用。研究表明，正常大脑中的 IL-6 水平较低，但在 CNS 损伤和疾病中可显著升高。目前对于升高的 IL-6 水平如何影响神经元知之甚少。在本研究中，我们表明在慢性暴露的情况下，IL-6 会诱导发育中的 CNS 细胞中蛋白质表达水平的改变。这种变化可能在与 CNS 中 IL-6 水平升高相关的 CNS 疾病中观察到的 CNS 功能改变中发挥作用。
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