Department of Surgery, Institute of Molecular Medicine, University of Dublin, Trinity College and St. James's Hospital Dublin, Dublin 8, Ireland.
Cancer Lett. 2011 Dec 15;312(1):62-72. doi: 10.1016/j.canlet.2011.07.034. Epub 2011 Aug 11.
Obesity has been associated with increased incidence and mortality of oesophageal and colorectal adenocarcinoma. Excess central adiposity may drive this association through an altered inflammatory milieu. Utilising a unique adipose tissue bioresource we aimed to determine the pro-tumour properties of visceral adipose tissue. Comparing subcutaneous and visceral adipose tissue depots, we observed significantly higher levels of VEGF and IL-6, along with significantly higher proportions of CD8(+) T cells and NKT cells in visceral adipose tissue. Significantly higher levels of VEGF were observed in the conditioned media from visceral adipose tissue of centrally obese compared to non-obese patients. We also report a significant increase in oesophageal and colorectal tumour cell proliferation following culture with conditioned media from visceral adipose tissue of centrally obese patients. Neutralising VEGF in the conditioned media significantly decreased tumour cell proliferation. This novel report highlights a potential mechanism whereby visceral adipose tissue from centrally obese cancer patients may drive tumour progression.
肥胖与食管和结直肠腺癌的发病率和死亡率增加有关。过多的中心性肥胖可能通过改变炎症环境来驱动这种关联。利用独特的脂肪组织生物资源，我们旨在确定内脏脂肪组织的促肿瘤特性。通过比较皮下和内脏脂肪组织储存库，我们观察到内脏脂肪组织中 VEGF 和 IL-6 的水平显著升高，以及 CD8(+)T 细胞和 NKT 细胞的比例显著升高。与非肥胖患者相比，来自中心性肥胖患者的内脏脂肪组织的条件培养基中观察到 VEGF 水平显著升高。我们还报告说，在用来自中心性肥胖患者的内脏脂肪组织的条件培养基培养后，食管和结直肠肿瘤细胞的增殖显著增加。在条件培养基中中和 VEGF 可显著降低肿瘤细胞增殖。这项新的报告强调了一种潜在的机制，即来自中心性肥胖癌症患者的内脏脂肪组织可能推动肿瘤进展。
