Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287, USA.
J Cyst Fibros. 2012 Jan;11(1):18-23. doi: 10.1016/j.jcf.2011.08.003. Epub 2011 Sep 3.
Cystic fibrosis (CF) lung disease leads to progressive deterioration in exercise capacity. Because physical activity has been shown to improve lung function and quality of life (QoL), developing routine exercise programs can benefit this patient population.
Lung function, nutritional status, and exercise capacity and assessments of habitual activity and QoL were measured before and after a two-month, subject-designed exercise regimen based on self-reported activity assessment. Statistical analysis included Wilcoxon signed-rank, Wilcoxon rank sum, and Fisher's exact tests.
Subjects completing the study demonstrated significant improvement in exercise capacity and body image perception, a CF-specific QoL measure (p<0.001). In secondary analyses, subjects improving exercise capacity showed significant increases in lung function and self-reported habitual activity.
Increases in exercise capacity over a two-month period resulted in significantly improved lung function and self-reported habitual activity. Longer, controlled trials are needed to develop individualized exercise recommendations.
囊性纤维化（CF）肺病导致运动能力逐渐恶化。由于体育活动已被证明可以改善肺功能和生活质量（QoL），因此制定常规运动计划可以使这一患者群体受益。
在基于自我报告活动评估的为期两个月的个性化运动方案后，测量肺功能、营养状况、运动能力以及习惯性活动和生活质量评估。统计分析包括 Wilcoxon 符号秩检验、Wilcoxon 秩和检验和 Fisher 确切检验。
完成研究的受试者在运动能力和身体形象感知方面（CF 特定生活质量衡量标准）表现出显著改善（p<0.001）。在次要分析中，运动能力提高的受试者的肺功能和自我报告的习惯性活动显著增加。
在两个月的时间内，运动能力的增加导致肺功能和自我报告的习惯性活动显著改善。需要进行更长时间、更严格的临床试验，以制定个性化的运动建议。
