Psychiatric University Hospital of Psychiatry Zurich, Zurich, Switzerland.
J Psychopharmacol. 2011 Dec;25(12):1600-13. doi: 10.1177/0269881111415734. Epub 2011 Sep 2.
Sensory gating, indexed by P50 suppression, and sensorimotor gating, indexed by prepulse inhibition (PPI), are impaired in schizophrenia spectrum disorders. There is considerable evidence that schizophrenia patients treated with atypical antipsychotics exhibit relatively less gating deficits than do other patients with schizophrenia. Some recent studies have investigated the effects of antipsychotic medications on gating in healthy volunteers exhibiting low levels of gating, rather than in patients. Therefore, the current study investigated the influence of sertindole versus placebo in two separate experimental sessions, on PPI, P50 suppression, and cognition in 30 male volunteers stratified for low and high baseline gating levels. Sertindole increased PPI and P50 suppression in healthy subjects exhibiting low baseline PPI and low baseline P50 suppression, respectively, while sertindole attenuated gating in subjects exhibiting high baseline gating. Furthermore, subjects exhibiting low PPI chose worse strategies in a spatial working memory task. These findings suggest that mixed D(2)/5-HT(2) receptor antagonists enhance both PPI and P50 suppression in a way that enhances it in healthy subjects exhibiting low baseline gating. Furthermore, the results militate in favor of the concomitant assessment of PPI, P50 suppression and cognitive measures while investigating the effect of antipsychotic medication in healthy subjects.
感觉门控，由 P50 抑制指数表示，以及感觉运动门控，由前脉冲抑制（PPI）指数表示，在精神分裂症谱系障碍中受损。有相当多的证据表明，与其他精神分裂症患者相比，接受非典型抗精神病药物治疗的精神分裂症患者表现出相对较少的门控缺陷。一些最近的研究调查了抗精神病药物对表现出低门控水平的健康志愿者的门控的影响，而不是对患者的影响。因此，本研究在两个单独的实验中调查了舍曲林与安慰剂对 30 名男性志愿者的影响，这些志愿者根据低和高基线门控水平进行分层。舍曲林分别增加了低基线 PPI 和低基线 P50 抑制的健康受试者的 PPI 和 P50 抑制，而舍曲林在基线门控水平较高的受试者中减弱了门控。此外，PPI 较低的受试者在空间工作记忆任务中选择了较差的策略。这些发现表明，混合 D2/5-HT2 受体拮抗剂以一种增强健康受试者低基线门控的方式增强了 PPI 和 P50 抑制。此外，这些结果支持在健康受试者中调查抗精神病药物的作用时同时评估 PPI、P50 抑制和认知测量。
