Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 200-701, Republic of Korea.
J Biol Chem. 2011 Oct 28;286(43):37841-8. doi: 10.1074/jbc.M111.232165. Epub 2011 Sep 2.
cAMP response element-binding protein (CREB) is one of the best known transcription factors in the development and function of the nervous system. In this report, we found that the regulator of calcineurin 1 (RCAN1), which is overexpressed in the brain of patients with Down syndrome, increased the phosphorylation of CREB and cAMP response element-mediated gene transcription in response to the activation of the intracellular cAMP pathway. Furthermore, we found that the increased activation of CREB signaling by RCAN1 depended on the ability of RCAN1 to inhibit calcineurin activity. Our data provide the first evidence that RCAN1 acts as an important regulatory component in the control of CREB signaling.
环磷酸腺苷反应元件结合蛋白（CREB）是神经系统发育和功能中最著名的转录因子之一。在本报告中，我们发现，在唐氏综合征患者的大脑中过度表达的钙调神经磷酸酶 1 调节因子（RCAN1），可响应细胞内 cAMP 途径的激活，增加 CREB 的磷酸化和 cAMP 反应元件介导的基因转录。此外，我们发现 RCAN1 对 CREB 信号的激活增加依赖于 RCAN1 抑制钙调神经磷酸酶活性的能力。我们的数据首次提供了证据表明，RCAN1 是 CREB 信号控制的重要调节成分。
