钙调神经磷酸酶 1 调节蛋白 1（RCAN1/DSCR1）激活环腺苷酸反应元件结合蛋白（CREB）通路。
The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway.
机构信息
Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 200-701, Republic of Korea.
出版信息
J Biol Chem. 2011 Oct 28;286(43):37841-8. doi: 10.1074/jbc.M111.232165. Epub 2011 Sep 2.
Abstract
cAMP response element-binding protein (CREB) is one of the best known transcription factors in the development and function of the nervous system. In this report, we found that the regulator of calcineurin 1 (RCAN1), which is overexpressed in the brain of patients with Down syndrome, increased the phosphorylation of CREB and cAMP response element-mediated gene transcription in response to the activation of the intracellular cAMP pathway. Furthermore, we found that the increased activation of CREB signaling by RCAN1 depended on the ability of RCAN1 to inhibit calcineurin activity. Our data provide the first evidence that RCAN1 acts as an important regulatory component in the control of CREB signaling.
摘要
环磷酸腺苷反应元件结合蛋白（CREB）是神经系统发育和功能中最著名的转录因子之一。在本报告中，我们发现，在唐氏综合征患者的大脑中过度表达的钙调神经磷酸酶 1 调节因子（RCAN1），可响应细胞内 cAMP 途径的激活，增加 CREB 的磷酸化和 cAMP 反应元件介导的基因转录。此外，我们发现 RCAN1 对 CREB 信号的激活增加依赖于 RCAN1 抑制钙调神经磷酸酶活性的能力。我们的数据首次提供了证据表明，RCAN1 是 CREB 信号控制的重要调节成分。
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The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway.钙调神经磷酸酶 1 调节蛋白 1（RCAN1/DSCR1）激活环腺苷酸反应元件结合蛋白（CREB）通路。
J Biol Chem. 2011 Oct 28;286(43):37841-8. doi: 10.1074/jbc.M111.232165. Epub 2011 Sep 2.
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本文引用的文献
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Upregulation of DSCR1 (RCAN1 or Adapt78) in the peri-infarct cortex after experimental stroke.实验性中风后梗死周围皮质中DSCR1（RCAN1或Adapt78）的上调。
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The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling.唐氏综合征关键区域蛋白RCAN1通过抑制磷酸酶信号传导来调节长时程增强和记忆。
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Calcineurin activity is required for depolarization-induced, CREB-dependent gene transcription in cortical neurons.钙调神经磷酸酶活性是皮层神经元中去极化诱导的、依赖CREB的基因转录所必需的。
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Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates.DSCR1的过表达通过形成核聚集体来阻止锌诱导的神经元细胞死亡。
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Regulation of NFAT activation: a potential therapeutic target for immunosuppression.NFAT 激活的调控：免疫抑制的潜在治疗靶点。
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The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways.垂体腺苷酸环化酶激活肽在PC12细胞中的神经营养作用：由多种转导途径调控
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Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia.钙蛋白酶产生的组成型活性钙调神经磷酸酶导致小鼠脑缺血后神经元延迟性死亡。
J Neurochem. 2006 Jul;98(1):310-20. doi: 10.1111/j.1471-4159.2006.03874.x.
9
Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease.DSCR1（Adapt78或RCAN1）基因及其蛋白产物钙调磷酸酶1（或RCAN1）在疾病中的多种作用。
Cell Mol Life Sci. 2005 Nov;62(21):2477-86. doi: 10.1007/s00018-005-5085-4.
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