du Bois R M
Brompton Hospital, London, UK.
Sarcoidosis. 1990 Mar;7(1):15-8.
Sarcoidosis is characterized by the accumulation of lymphocytes and cells of the mononuclear phagocyte series (MPS) at sites of inflammation. MPS cells are central to the granulomatous response being capable of antigen presentation to T-cells, production of the potent monokines, IL-1 and TNF-alpha, and the secretion of growth factors, all of which are of likely relevance to the disease process. Bronchoalveolar lavage, monoclonal antibodies and molecular biology techniques have been invaluable tools in our understanding of the inflammation. These approaches will continue to be critical to resolving important questions relating to disease pathogenesis and treatment.
结节病的特征是淋巴细胞和单核吞噬细胞系列（MPS）细胞在炎症部位积聚。MPS细胞在肉芽肿反应中起核心作用，能够向T细胞呈递抗原、产生强效单核因子白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）以及分泌生长因子，所有这些都可能与疾病进程相关。支气管肺泡灌洗、单克隆抗体和分子生物学技术一直是我们理解炎症的宝贵工具。这些方法对于解决与疾病发病机制和治疗相关的重要问题仍将至关重要。
