Davis C E
Department of Biostatistics, University of North Carolina, Chapel Hill 27599-7400.
Stat Med. 1990 Jan-Feb;9(1-2):97-100. doi: 10.1002/sim.4780090116.
Ancillary questions in clinical trials can often be answered by studying subcohorts of the participants. If the question compares responses between treatment groups, a subcohort that preserves the randomization can be used. However, if the question can be answered by analysis within a treatment group or by combining treatment groups, efficient methods developed for observational studies can be used. These methods include case-control and case-cohort methods.
临床试验中的辅助问题通常可以通过研究参与者的亚组来回答。如果问题是比较治疗组之间的反应，可以使用保持随机化的亚组。然而，如果问题可以通过治疗组内的分析或合并治疗组来回答，那么可以使用为观察性研究开发的有效方法。这些方法包括病例对照法和病例队列法。
