Koduganti Rekha Rani, Sandeep N, Guduguntla Srikanth, Chandana Gorthi V S S
Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Kamala Nagar, Hyderabad, India.
Indian J Dent Res. 2011 Mar-Apr;22(2):324-30. doi: 10.4103/0970-9290.84312.
There has been a paradigm shift toward ecological and microbial community-based approach in understanding oral diseases. A marked improvement in gastrointestinal health has been reported after using probiotic bacteria and/or prebiotic supplements,which has prompted much interest in the use of this approach for oral applications. Treatment of periodontal disease in recent years has moved toward an antibiotic/antimicrobial model of disease management. With increase in the incidence of resistance to antibiotics, probiotics may be a promising area of research in periodontal therapy. This paper reviews the evidences for the use of probiotics or prebiotics for the prevention of dental caries or periodontal diseases, and also adresses the risk associated with their prolonged use. Many questions have been raised pertaining to the benefits of probiotic administration, as the role of probiotics in periodontics is still in infancy, and a complete understanding of the broad ecological changes induced in the mouth by probiotics or prebiotics is essential to assess their long-term consequences for oral health and disease.
在理解口腔疾病方面，已经出现了向基于生态和微生物群落的方法的范式转变。在使用益生菌和/或益生元补充剂后，胃肠道健康有了显著改善，这引发了人们对将这种方法用于口腔应用的极大兴趣。近年来，牙周疾病的治疗已朝着疾病管理的抗生素/抗菌模型发展。随着对抗生素耐药性的增加，益生菌可能是牙周治疗中一个有前景的研究领域。本文综述了使用益生菌或益生元预防龋齿或牙周疾病的证据，并讨论了长期使用它们的相关风险。由于益生菌在牙周病学中的作用仍处于起步阶段，关于益生菌给药的益处已经提出了许多问题，全面了解益生菌或益生元在口腔中引起的广泛生态变化对于评估它们对口腔健康和疾病的长期影响至关重要。
