McGill University, Physiology and Artificial Cells and Organs Research Centre, Departments of Biomedical Engineering, Biomedical Technology and Cell Therapy, Research Laboratory, Faculty of Medicine, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
Expert Opin Biol Ther. 2012 Sep;12(9):1207-20. doi: 10.1517/14712598.2012.693474. Epub 2012 Jun 13.
Oral health is affected by its resident microorganisms. Three prominent oral disorders are dental caries, gingivitis and periodontitis, with the oral microbiota playing a key role in the initiation/progression of all three. Understanding the microbiota and the diseases they may cause is critical to the development of new therapeutics. This review is focused on probiotics for the prevention and/or treatment of oral diseases.
This review describes the oral ecosystem and its correlation with oral health/disease. The pathogenesis and current prevention/treatment strategies of periodontal diseases (PD) and dental caries (DC) are depicted. An introduction of probiotics is followed by an analysis of their role in PD and DC, and their potential role(s) in oral health. Finally, a discussion ensues on the future research directions and limitations of probiotics for oral health.
An effective oral probiotic formulation should contribute to the prevention/treatment of microbial diseases of the oral cavity. Understanding the oral microbiota's role in oral disease is important for the development of a therapeutic to prevent/treat dental diseases. However, investigations into clinical efficacy, delivery/dose optimization, mechanism(s) of action and other related parameters are yet to be fully explored. Keeping this in mind, investigations into oral probiotic therapies are proving promising.
口腔健康受常驻微生物的影响。三种主要的口腔疾病是龋齿、牙龈炎和牙周炎，口腔微生物群在这三种疾病的发生和进展中起着关键作用。了解微生物群及其可能引起的疾病对于开发新的治疗方法至关重要。本综述重点介绍了用于预防和/或治疗口腔疾病的益生菌。
本综述描述了口腔生态系统及其与口腔健康/疾病的相关性。描述了牙周病 (PD) 和龋齿 (DC) 的发病机制和当前的预防/治疗策略。介绍了益生菌，然后分析了它们在 PD 和 DC 中的作用及其在口腔健康中的潜在作用。最后，讨论了益生菌在口腔健康方面的未来研究方向和局限性。
有效的口腔益生菌配方应该有助于预防/治疗口腔微生物疾病。了解口腔微生物群在口腔疾病中的作用对于开发预防/治疗牙科疾病的治疗方法很重要。然而，关于临床疗效、给药/剂量优化、作用机制和其他相关参数的研究仍有待充分探索。考虑到这一点，对口腔益生菌疗法的研究正在取得进展。
