Dybkaer R
Department of Clinical Chemistry, Frederiksberg Hospital, DK.
Scand J Clin Lab Invest Suppl. 1990;198:20-5.
Quantities in blood, plasma, or serum having lipid components are often difficult to define, especially as regards the component which must be selected according to chemical, biological, and clinical considerations. The choice of generic quantities and their respective measurement procedures relates to clinical requirements of allowable uncertainty, effectiveness, comparability, and compatibility determining goals of analytical reliability. The measurement procedure should define preanalytical requirements and be based upon traceability from tertiary and secondary reference materials with reference procedure values to primary reference materials. Such materials and procedures should be established internationally. A comprehensive quality assurance system of internal quality control and external quality assessment is essential to ensure worldwide and continued comparability. Validation and transferability should also be demonstrated by regional or international collaboration. Transmutation of results between procedures requires extensive investigations.
血液、血浆或血清中含有脂质成分的量通常难以界定，尤其是对于必须根据化学、生物学和临床考量来选择的成分而言。通用量及其各自测量程序的选择涉及到可接受不确定度、有效性、可比性和兼容性等临床要求，这些要求决定了分析可靠性的目标。测量程序应界定分析前的要求，并基于从具有参考程序值的三级和二级参考物质到一级参考物质的溯源性。此类物质和程序应在国际上确立。内部质量控制和外部质量评估的全面质量保证体系对于确保全球范围内的持续可比性至关重要。验证和可转移性也应通过区域或国际合作来证明。不同程序之间结果的转换需要进行广泛的研究。
