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一体化FDG PET/CT：在临床肿瘤学中的应用与效用

Integrated FDG PET/CT: Utility and Applications in Clinical Oncology.

作者信息

Pinilla Inmaculada, Rodríguez-Vigil Beatriz, Gómez-León Nieves

机构信息

Department of Radiology, Hospital Universitario La Paz, Madrid, Spain.

出版信息

Clin Med Oncol. 2008;2:181-98. doi: 10.4137/cmo.s504. Epub 2008 Sep 19.

DOI:10.4137/cmo.s504
PMID:21892279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3161686/
Abstract

Accurate diagnosis and staging are essential for an optimal management of cancer patients. Positron emision tomography with 2-deoxy-2-fluorine-18-fluoro-D-glucose ((18)FDG-PET) and, more recently, (18)FDG-PET/computed tomography ((18)FDG-PET/CT) have emerged as powerful imaging tools in oncology, because of the valuable functional information they provide. The combined acquisition of PET and CT has synergistic advantages over its isolated constituents and minimizes their limitations. It decreases examination times by 25%-40%, leads to a higher patient throughput and unificates two imaging procedures in a single session. There is evidence that (18)FDG-PET/CT is a more accurate test than either of its components for the evaluation of various tumors. It is a particularly valuable tool for detection of recurrence, especially in asymptomatic patients with rising tumor markers and those with negative or equivocal findings on conventional imaging tests. Yet, there are some limitations and areas of uncertainty, mainly regarding the lack of specificity of the (18)FDG uptake and the variable (18)FDG avidity of some cancers. This article reviews the advantages, limitations and main applications of (18)FDG-PET/CT in oncology, with especial emphasis on lung cancer, colorectal cancer, lymphomas, melanoma and head and neck cancers.

摘要

准确的诊断和分期对于癌症患者的优化管理至关重要。正电子发射断层扫描结合2-脱氧-2-氟-18-氟-D-葡萄糖（(18)FDG-PET），以及最近出现的(18)FDG-PET/计算机断层扫描（(18)FDG-PET/CT），已成为肿瘤学中强大的成像工具，因为它们能提供有价值的功能信息。PET和CT的联合采集相对于其单独的组成部分具有协同优势，并最大限度地减少了它们的局限性。它将检查时间减少了25%-40%，提高了患者通量，并在一次检查中整合了两种成像程序。有证据表明，对于各种肿瘤的评估，(18)FDG-PET/CT比其任何一个组成部分都是更准确的检查。它是检测复发的特别有价值的工具，尤其是在肿瘤标志物升高的无症状患者以及传统成像检查结果为阴性或不明确的患者中。然而，也存在一些局限性和不确定的领域，主要涉及(18)FDG摄取缺乏特异性以及某些癌症的(18)FDG亲和力可变。本文综述了(18)FDG-PET/CT在肿瘤学中的优势、局限性和主要应用，特别强调了肺癌、结直肠癌、淋巴瘤、黑色素瘤和头颈癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/949c4853029d/cmo-2-2008-181f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/de247e09f449/cmo-2-2008-181f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/14374c4791a7/cmo-2-2008-181f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/9821988b83c4/cmo-2-2008-181f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/d7c9ddab0ea5/cmo-2-2008-181f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/be08d4a8744f/cmo-2-2008-181f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/949c4853029d/cmo-2-2008-181f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/de247e09f449/cmo-2-2008-181f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/ecd57e1e8025/cmo-2-2008-181f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/9167669e255c/cmo-2-2008-181f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/ff3c33420112/cmo-2-2008-181f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/14374c4791a7/cmo-2-2008-181f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/9821988b83c4/cmo-2-2008-181f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/d7c9ddab0ea5/cmo-2-2008-181f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cbf/3161686/be08d4a8744f/cmo-2-2008-181f9.jpg
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