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一种与同步放化疗治疗局部晚期头颈癌相关的独特并发症。

A unique complication associated with concurrent chemoradiation for the treatment of locally advanced head and neck cancer.

作者信息

Cahlon Oren, Shaha Ashok, Lee Nancy

机构信息

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.

出版信息

Clin Med Oncol. 2008;2:313-8. doi: 10.4137/cmo.s407. Epub 2008 Apr 1.

DOI:10.4137/cmo.s407
PMID:21892292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3161639/
Abstract

BACKGROUND

Concurrent chemoradiation is becoming an increasingly popular treatment for patients with locally advanced head and neck cancer. The full extent of treatment related complications has not been completely documented in the literature.

METHODS

We present the case of a patient treated with definitive intensity modulated radiation therapy and concurrent carboplatin and fluorouracil for a locally advanced oral cavity and base of tongue cancer.

RESULTS

The patient suffered acute grade 4 dermatitis and mucositis during treatment. One month after completion of treatment, the patient was found to have permanent adherence of the tongue to the buccal mucosa as a result of severe scar tissue formation.

CONCLUSIONS

As more patients undergo chemoradiation for the treatment of locally advanced head and neck cancer, the full extent of treatment related complications are being identified. To our knowledge, this is the first report of chemoradiation for head and neck cancer resulting in adherence of the tongue to the buccal mucosa.

摘要

背景

同步放化疗正日益成为局部晚期头颈癌患者的常用治疗方法。治疗相关并发症的全部情况尚未在文献中得到完整记录。

方法

我们报告一例接受确定性调强放疗及同步使用卡铂和氟尿嘧啶治疗的局部晚期口腔癌和舌根部癌患者的病例。

结果

患者在治疗期间出现了4级急性皮炎和黏膜炎。治疗结束后一个月，发现患者因严重瘢痕组织形成导致舌与颊黏膜永久性粘连。

结论

随着越来越多的患者接受同步放化疗来治疗局部晚期头颈癌，治疗相关并发症的全部情况正在被发现。据我们所知，这是头颈部癌同步放化疗导致舌与颊黏膜粘连的首例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/2c92bffe9eef/cmo-2-2008-313f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/546082256d7d/cmo-2-2008-313f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/10a56cd97250/cmo-2-2008-313f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/275a1711a42c/cmo-2-2008-313f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/108da20175e4/cmo-2-2008-313f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/2c92bffe9eef/cmo-2-2008-313f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/546082256d7d/cmo-2-2008-313f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/10a56cd97250/cmo-2-2008-313f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/275a1711a42c/cmo-2-2008-313f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/108da20175e4/cmo-2-2008-313f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db27/3161639/2c92bffe9eef/cmo-2-2008-313f5.jpg

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本文引用的文献

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Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab.头颈部癌患者单纯接受高剂量放疗或联合西妥昔单抗治疗后的生活质量。
J Clin Oncol. 2007 Jun 1;25(16):2191-7. doi: 10.1200/JCO.2006.08.8005.
2
Concurrent chemotherapy and intensity-modulated radiotherapy for locoregionally advanced laryngeal and hypopharyngeal cancers.同步化疗与调强放疗用于局部晚期喉癌和下咽癌的治疗
Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):459-68. doi: 10.1016/j.ijrobp.2007.03.013. Epub 2007 May 9.
3
A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma.
局部晚期口咽癌同步化疗时调强放射治疗与同期增量放疗的比较。
Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4):966-74. doi: 10.1016/j.ijrobp.2006.06.040.
4
Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation.喉癌和口咽癌患者放化疗后的生活质量结果
Otolaryngol Head Neck Surg. 2006 Oct;135(4):565-70. doi: 10.1016/j.otohns.2006.06.1266.
5
Quality of life in advanced oropharyngeal carcinoma after chemoradiation versus surgery and radiation.放化疗与手术联合放疗治疗晚期口咽癌后的生活质量对比
Laryngoscope. 2006 Sep;116(9):1589-93. doi: 10.1097/01.mlg.0000233244.18901.44.
6
Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study.头颈部癌放化疗期间静脉注射氨磷汀：一项随机安慰剂对照III期研究。
Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):684-91. doi: 10.1016/j.ijrobp.2005.08.005. Epub 2005 Oct 21.
7
Matched case-control study of quality of life and xerostomia after intensity-modulated radiotherapy or standard radiotherapy for head-and-neck cancer: initial report.头颈部癌调强放疗或标准放疗后生活质量与口干症的配对病例对照研究：初步报告
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8
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