英国和尼日利亚乳腺癌女性患者的临床病理特征及分子标志物比较
A comparison of clinicopathological features and molecular markers in british and nigerian women with breast cancer.
作者信息
Gukas Isaac D, Girling Anne C, Mandong Barnabas M, Prime Wendy, Jennings Barbara A, Leinster Samuel J
机构信息
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR47TJ, U.K.
出版信息
Clin Med Oncol. 2008;2:347-51. doi: 10.4137/cmo.s474. Epub 2008 Apr 24.
BACKGROUND
Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study's aim was to look for evidence of differences in tumour biology between the two cohorts.
METHODS
This study compared the stage, grade and pathological expression of five immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks.
RESULTS
There were significant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no significant differences were observed for tumour grade.
CONCLUSION
There was a significantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely influence prognosis between Nigerian and British women with breast cancer.
背景
一些研究表明，黑人女性的乳腺癌比白人女性的更具侵袭性。本研究的目的是寻找这两个队列之间肿瘤生物学差异的证据。
方法
本研究比较了来自尼日利亚和英国年龄匹配患者队列的肿瘤活检中五个免疫组化标志物（雌激素受体[ER]、孕激素受体[PR]、ERBB2、P53和细胞周期蛋白D1[CCND1]）的分期、分级和病理表达。从组织学组织库中检索了68份来自尼日利亚（n = 34）和英国（n = 34）乳腺癌患者的合适样本。
结果
两个队列在ER和CCND1的表达上存在显著差异；在就诊时的临床分期上存在明显差异。但未观察到肿瘤分级有显著差异。
结论
尼日利亚病例中ER表达显著较低，这也预示着对激素治疗反应不佳以及预后较差。就诊时临床分期的差异很可能会影响尼日利亚和英国乳腺癌女性之间的预后。
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