Titloye N A, Foster A, Omoniyi-Esan G O, Komolafe A O, Daramola A O, Adeoye O A, Adisa A O, Manoharan A, Pathak D, D'Cruz M N, Alizadeh Y, Lewis P D, Shaaban A M
School of Medical Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Pathobiology. 2016;83(1):24-32. doi: 10.1159/000441949. Epub 2016 Jan 6.
Little is known about the biology, molecular profile and hence optimal treatment of African Nigerian breast cancer. The aim of this work, therefore, was to characterize the histology and molecular profile of Nigerian breast cancer.
Breast carcinomas from women at 6 centres of similar tribal origin in Nigeria were reviewed and assembled into tissue microarrays (TMAs), and sections were stained for hormone receptors, i.e. estrogen receptor (ER)α, ERβ1, ERβ progesterone receptor (PR) and androgen receptor, cyclin D, HER2, Ki67 and cytokeratins (CKs), i.e. CK5/6 and CK14 (basal) and CK18 and 19 (luminal).
A total of 835 tumours were analysed. The mean age at diagnosis was 48.62 ± 12.41 years. The most common histological subtype was ductal NST (no-special-type) carcinoma (87.3%). Over 90% of the tumours were grade 2 or 3. The predominant molecular phenotype was the non-basal, triple-negative type (47.65%) followed by the HER2-positive group (19.6%). The percentage of ER-, PR- and HER2-positive tumours was 22.4, 18.9 and 18.8%, respectively.
Nigerian breast cancer predominantly has a high-grade, triple-negative profile. It occurs at a younger age and bears similarities at the molecular level to pre-menopausal breast cancer in white women, with remarkably lower levels of ERβ expression. The early presentation and histological and molecular phenotype may explain the poor prognosis, and tailoring treatment strategies to target this unique profile are required.
对于非洲尼日利亚乳腺癌的生物学特性、分子特征以及最佳治疗方法，我们了解甚少。因此，本研究的目的是对尼日利亚乳腺癌的组织学和分子特征进行描述。
对来自尼日利亚6个部落起源相似的中心的女性乳腺癌进行回顾性分析，并将其制成组织微阵列（TMA），切片进行激素受体染色，即雌激素受体（ER）α、ERβ1、ERβ、孕激素受体（PR）和雄激素受体、细胞周期蛋白D、HER2、Ki67以及细胞角蛋白（CK），即CK5/6和CK14（基底型）以及CK18和19（管腔型）。
共分析了835例肿瘤。诊断时的平均年龄为48.62±12.41岁。最常见的组织学亚型是导管非特殊型（NST）癌（87.3%）。超过90%的肿瘤为2级或3级。主要的分子表型是非基底型三阴性类型（47.65%），其次是HER2阳性组（19.6%）。ER、PR和HER2阳性肿瘤的百分比分别为22.4%、18.9%和18.8%。
尼日利亚乳腺癌主要具有高级别、三阴性特征。它发病年龄较轻，在分子水平上与白人女性绝经前乳腺癌相似，但ERβ表达水平明显较低。早期发病以及组织学和分子表型可能解释了其预后较差的原因，需要制定针对这种独特特征的治疗策略。
