Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078-900, Natal, RN, Brazil.
Laboratory of Technology Pharmaceutical, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil.
Mar Drugs. 2011;9(8):1332-1345. doi: 10.3390/md9081332. Epub 2011 Aug 10.
The regulation of the inflammatory response is essential to maintaining homeostasis. Several studies have investigated new drugs that may contribute to avoiding or minimizing excessive inflammatory process. The aim of this study was to evaluate the effect of extracts of green algae Caulerpa mexicana on models inflammation. In mice, the inflammatory peritonitis model is induced by zymosan. Previous treatment of mice with aqueous and methanolic extracts of C. mexicana was able to suppress the cell migration to the peritoneal cavity, in a time-dependent but not in a dose-dependent manner. The treatment of mice with C. mexicana extracts also decreased the xylene-induced ear edema, exerting strong inhibitory leukocyte migration elicited by zymosan into the air pouch. We concluded that administration of the extracts resulted in a reduction of cell migration to different sites as well as a decrease in edema formation induced by chemical irritants. This study demonstrates for the first time the anti-inflammatory effect of aqueous and methanolic extracts from the green marine algae Caulerpa mexicana.
炎症反应的调节对于维持内环境平衡至关重要。已有多项研究探索了可能有助于避免或最小化过度炎症过程的新药。本研究旨在评估绿藻石莼（Caulerpa mexicana）提取物对炎症模型的影响。在小鼠中，通过酵母聚糖诱导炎症性腹膜炎模型。先前用绿藻石莼的水提物和甲醇提取物对小鼠进行预处理，能够抑制细胞向腹腔的迁移，但这种抑制作用既不是时间依赖性的，也不是剂量依赖性的。用绿藻石莼提取物处理小鼠还可减轻二甲苯诱导的耳部水肿，对酵母聚糖诱导的气囊中白细胞迁移产生强烈的抑制作用。我们得出结论，提取物的给药导致向不同部位的细胞迁移减少，以及由化学刺激物引起的水肿形成减少。本研究首次证明了来自绿海藻石莼的水提物和甲醇提取物的抗炎作用。
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