de Lalla F, Rizzardini G, Rinaldi E, Santoro D, Zeli P L, Verga G
Department of Infectious Diseases, S. Anna Hospital, Como, Italy.
Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):144-7. doi: 10.1016/0035-9203(90)90412-8.
In order to compare the seroepidemiology of human immunodeficiency virus (HIV), hepatitis B virus, delta agent and Treponema pallidum infections in two rural populations living in north Uganda (Kitgum district) and in central Burundi (Butezi, Ruyigi region), 448 sera were tested for HBS-Ag, HBS-Ab, and anti-HIV antibodies and screened for syphilis using the T. pallidum haemagglutination (TPHA) test. HBS-Ag positive sera were also tested for anti-delta antibodies. Overall seropositivity rates in healthy subjects, outpatients and inpatients (non-AIDS) were 14.2% and 9.5% in Kitgum district and Butezi, respectively. The prevalence of HBS-Ag and HBS-Ab ranged from 10.0% to 15.6% and from 66.2% to 68.9%, respectively. In north Uganda the rates of anti-delta positivity were 3.1% in the overall population and 30.6% in the HBS-Ag positive subjects. No serum obtained in Butezi was anti-delta positive. In Ugandan people, 64.0% of anti-HIV positive and 25.8% of anti-HIV negative patients were also TPHA-positive (P less than 0.01). For Butezi the corresponding figures were 21.4% and 1.6% respectively (P less than 0.04). On the contrary, no correlation was found between either anti-HIV or TPHA positives and seropositivity for B and delta hepatitis serological markers. The study demonstrated an association between seropositivities for HIV and T. pallidum (TPHA), suggesting common patterns of transmission. On the contrary, no association seemed to exist between HBV and HIV infections.
为比较乌干达北部（基特古姆区）和布隆迪中部（鲁伊吉地区布泰齐）两个农村人群中人类免疫缺陷病毒（HIV）、乙型肝炎病毒、丁型肝炎病毒和梅毒螺旋体感染的血清流行病学情况，对448份血清进行了乙肝表面抗原（HBS-Ag）、乙肝表面抗体（HBS-Ab）和抗HIV抗体检测，并采用梅毒螺旋体血凝试验（TPHA）筛查梅毒。对HBS-Ag阳性血清还检测了抗丁型肝炎抗体。基特古姆区和布泰齐健康受试者、门诊患者和住院患者（非艾滋病患者）的总体血清阳性率分别为14.2%和9.5%。HBS-Ag和HBS-Ab的患病率分别为10.0%至15.6%和66.2%至68.9%。在乌干达北部，总体人群中抗丁型肝炎阳性率为3.1%，HBS-Ag阳性受试者中为30.6%。在布泰齐采集的血清中没有抗丁型肝炎阳性的。在乌干达人群中，64.0%的抗HIV阳性患者和25.8%的抗HIV阴性患者TPHA也呈阳性（P<0.01）。布泰齐的相应数字分别为21.4%和1.6%（P<0.04）。相反，抗HIV或TPHA阳性与乙型和丁型肝炎血清学标志物的血清阳性之间均未发现相关性。该研究表明HIV和梅毒螺旋体（TPHA）血清阳性之间存在关联，提示存在共同的传播模式。相反，HBV和HIV感染之间似乎不存在关联。
