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一种克级规模合成的多 13C 标记花色苷，[6,8,10,3',5'-13C5]矢车菊素-3-葡萄糖苷，用于人体口服示踪研究。

A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3',5'-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans.

机构信息

University of St Andrews, EaStChem School of Chemistry and Centre for Biomolecular Sciences, North Haugh, St Andrews, Fife, KY16 9ST, UK.

出版信息

Chem Commun (Camb). 2011 Oct 14;47(38):10596-8. doi: 10.1039/c1cc14323a. Epub 2011 Sep 5.

DOI:10.1039/c1cc14323a
PMID:21892498
Abstract

The major dietary anthocyanin, cyanidin-3-glucoside, was prepared on a 4 g scale from three units of diethyl [2-(13)C]malonate and one unit of [1,3-(13)C(2)]acetone, such that five isotope locations were distributed throughout the molecule to provide a penta-(13)C(5)-labelled anthocyanin, [6,8,10,3',5'-(13)C(5)]cyanidin-3-glucoside chloride, for use in human stable-isotope tracer studies.

摘要

主要的饮食类花青素，矢车菊素-3-葡萄糖苷，在 4 克规模上从三个单元的二乙基 [2-(13)C]丙二酸酯和一个单元的 [1,3-(13)C(2)]丙酮制备，使得五个同位素位置分布在整个分子中，以提供一个全-(13)C(5)-标记的花青素，[6,8,10,3',5'-(13)C(5)]矢车菊素-3-葡萄糖苷氯化物，用于人类稳定同位素示踪研究。

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