Ennes Dourado Ferro F, de Sousa Lima V B, Mello Soares N R, Franciscato Cozzolino S Ma, do Nascimento Marreiro D
Nutr Hosp. 2011 May-Jun;26(3):650-4. doi: 10.1590/S0212-16112011000300032.
Obesity is a chronic disease that induces risk factors for metabolic syndrome and, is associated with disturbances in the metabolism of the zinc. Therefore, the aim of this study was to investigate the existence of relationship between the biomarkers of metabolic syndrome and the zinc nutricional status in obese women.
Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37) and control group, composed of no obese (n = 36). The assessment of the body mass index and waist circumference were carried out using anthropometric measurements. The plasmatic and erythrocytary zinc were analyzed by method atomic absorption spectrophotometry (λ = 213.9 nm).
In the study, body mass index and waist circumference were higher in obese women than control group (p < 0.05). The mean plasmatic zinc was 72.2 ± 9.0 μg/dl in obese women and 73.4 ± 8.5 μg/dl in control group (p > 0.05). The mean erythrocytary zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb in the obese and controls, respectively (p < 0.05). Regression analysis showed that the body mass index (t =-2.85) and waist circumference (t = -2.37) have a negative relationship only with the erythrocytary zinc (R² = 0.32, p < 0.05).
The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocytary zinc is influenced by biomarkers of the metabolic syndrome, presenting an inverse relationship with the waist circumference and body mass index.
肥胖是一种慢性疾病，会引发代谢综合征的危险因素，且与锌代谢紊乱有关。因此，本研究的目的是调查肥胖女性代谢综合征生物标志物与锌营养状况之间是否存在关联。
73名年龄在20至50岁之间的绝经前女性被分为两组：病例组，由肥胖女性组成（n = 37）；对照组，由非肥胖女性组成（n = 36）。通过人体测量法评估体重指数和腰围。采用原子吸收分光光度法（λ = 213.9 nm）分析血浆和红细胞中的锌含量。
在本研究中，肥胖女性的体重指数和腰围高于对照组（p < 0.05）。肥胖女性的血浆锌平均含量为72.2 ± 9.0 μg/dl，对照组为73.4 ± 8.5 μg/dl（p > 0.05）。肥胖组和对照组的红细胞锌平均含量分别为36.4 ± 15.0 μg/gHb和45.4 ± 14.3 μg/gHb（p < 0.05）。回归分析表明，体重指数（t = -2.85）和腰围（t = -2.37）仅与红细胞锌呈负相关（R² = 0.32，p < 0.05）。
该研究表明肥胖女性的锌生化参数存在改变，红细胞中锌浓度较低。回归分析表明，红细胞锌受代谢综合征生物标志物的影响，与腰围和体重指数呈负相关。
